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Merck & Co posaconazole (posa)
Posaconazole (Posa), supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/posaconazole+(posa)/posaconazole+pos/ppr0311220-42-0-2
Average 90 stars, based on 1 article reviews
posaconazole (posa) - by Bioz Stars, 2026-08
90/100 stars

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Compounds used in this study, their mode of action, and medical use.

Journal: Frontiers in Cellular and Infection Microbiology

Article Title: Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

doi: 10.3389/fcimb.2021.617917

Figure Lengend Snippet: Compounds used in this study, their mode of action, and medical use.

Article Snippet: Amitryptiline (hydrochloride), FTY720, FTY720 phosphate, AMP-deoxynojirimicin, D609 (potassium salt), fumonisin B1, myriocin, Ro48-8071, TMP-153, GW4869 (hydrochloride hydrate), PDMP (hydrochloride), tomatidine hydrochloride (TH) were purchased from Cayman chemicals and bezafibrate, quinuclidine hydrochloride, 3-aminoquinuclidine dihydrochloride, and posaconazole (Posa) were from Sigma-Aldrich Switzerland.

Techniques: Activation Assay

Activity (EC 50 and EC 90 , µM, n = 3) and selectivity of lipid biosynthesis inhibitors on Trypanosoma cruzi epimastigotes (STIB 980 strain) and intracellular amastigotes (Tulahuen strain in rat L6 myoblasts).

Journal: Frontiers in Cellular and Infection Microbiology

Article Title: Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

doi: 10.3389/fcimb.2021.617917

Figure Lengend Snippet: Activity (EC 50 and EC 90 , µM, n = 3) and selectivity of lipid biosynthesis inhibitors on Trypanosoma cruzi epimastigotes (STIB 980 strain) and intracellular amastigotes (Tulahuen strain in rat L6 myoblasts).

Article Snippet: Amitryptiline (hydrochloride), FTY720, FTY720 phosphate, AMP-deoxynojirimicin, D609 (potassium salt), fumonisin B1, myriocin, Ro48-8071, TMP-153, GW4869 (hydrochloride hydrate), PDMP (hydrochloride), tomatidine hydrochloride (TH) were purchased from Cayman chemicals and bezafibrate, quinuclidine hydrochloride, 3-aminoquinuclidine dihydrochloride, and posaconazole (Posa) were from Sigma-Aldrich Switzerland.

Techniques: Activity Assay

Sum of the mean fractional inhibitory concentration indices (ΣFICI) of the combinations between Ro48-8071 or tomatidine hydrochloride and benznidazole,  posaconazole,  or fexinidazole in different fixed ratio proportions (1:3, 1:1, and 3:1; the first number corresponds to the standard drug) against T. cruzi intracellular amastigotes (strain Tulahuen in L6 cell lines).

Journal: Frontiers in Cellular and Infection Microbiology

Article Title: Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

doi: 10.3389/fcimb.2021.617917

Figure Lengend Snippet: Sum of the mean fractional inhibitory concentration indices (ΣFICI) of the combinations between Ro48-8071 or tomatidine hydrochloride and benznidazole, posaconazole, or fexinidazole in different fixed ratio proportions (1:3, 1:1, and 3:1; the first number corresponds to the standard drug) against T. cruzi intracellular amastigotes (strain Tulahuen in L6 cell lines).

Article Snippet: Amitryptiline (hydrochloride), FTY720, FTY720 phosphate, AMP-deoxynojirimicin, D609 (potassium salt), fumonisin B1, myriocin, Ro48-8071, TMP-153, GW4869 (hydrochloride hydrate), PDMP (hydrochloride), tomatidine hydrochloride (TH) were purchased from Cayman chemicals and bezafibrate, quinuclidine hydrochloride, 3-aminoquinuclidine dihydrochloride, and posaconazole (Posa) were from Sigma-Aldrich Switzerland.

Techniques: Concentration Assay

Isobologram showing the sum of the fractional inhibitory concentration indexes (∑FICI) of tomatidine hydrochloride and posaconazole, demonstrating the synergistic interaction of the combination in different fixed ratio proportions (1:3, 1:1, and 3:1) against T. cruzi intracellular amastigotes (strain Tulahuen in L6 cells). ∑FICI ≤ 0.5 = synergism; 0.5 < ∑FIC ≤ 4.0 = additive (no interaction); ∑FICI > 4.0 = antagonism.

Journal: Frontiers in Cellular and Infection Microbiology

Article Title: Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

doi: 10.3389/fcimb.2021.617917

Figure Lengend Snippet: Isobologram showing the sum of the fractional inhibitory concentration indexes (∑FICI) of tomatidine hydrochloride and posaconazole, demonstrating the synergistic interaction of the combination in different fixed ratio proportions (1:3, 1:1, and 3:1) against T. cruzi intracellular amastigotes (strain Tulahuen in L6 cells). ∑FICI ≤ 0.5 = synergism; 0.5 < ∑FIC ≤ 4.0 = additive (no interaction); ∑FICI > 4.0 = antagonism.

Article Snippet: Amitryptiline (hydrochloride), FTY720, FTY720 phosphate, AMP-deoxynojirimicin, D609 (potassium salt), fumonisin B1, myriocin, Ro48-8071, TMP-153, GW4869 (hydrochloride hydrate), PDMP (hydrochloride), tomatidine hydrochloride (TH) were purchased from Cayman chemicals and bezafibrate, quinuclidine hydrochloride, 3-aminoquinuclidine dihydrochloride, and posaconazole (Posa) were from Sigma-Aldrich Switzerland.

Techniques: Concentration Assay

Parasitemia and cumulative mortality of mice infected with T. cruzi (Y strain) treated with vehicle alone, posaconazole (Posa 10 and 1.25 mpk), or tomatidine hydrochloride (TH 5, 3.75 and 0.5 mpk) administrated for ten consecutive days (dpi 5 to 14).

Journal: Frontiers in Cellular and Infection Microbiology

Article Title: Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

doi: 10.3389/fcimb.2021.617917

Figure Lengend Snippet: Parasitemia and cumulative mortality of mice infected with T. cruzi (Y strain) treated with vehicle alone, posaconazole (Posa 10 and 1.25 mpk), or tomatidine hydrochloride (TH 5, 3.75 and 0.5 mpk) administrated for ten consecutive days (dpi 5 to 14).

Article Snippet: Amitryptiline (hydrochloride), FTY720, FTY720 phosphate, AMP-deoxynojirimicin, D609 (potassium salt), fumonisin B1, myriocin, Ro48-8071, TMP-153, GW4869 (hydrochloride hydrate), PDMP (hydrochloride), tomatidine hydrochloride (TH) were purchased from Cayman chemicals and bezafibrate, quinuclidine hydrochloride, 3-aminoquinuclidine dihydrochloride, and posaconazole (Posa) were from Sigma-Aldrich Switzerland.

Techniques: Infection

Parasitemia and cumulative mortality of mice infected with T. cruzi (Y strain) treated with vehicle or different co-administration proportions of posaconazole and tomatidine hydrochloride (Posa 1.25 + TH 5, Posa 1.25 + TH 3.75 and Posa 1.25 + TH 0.5 mpk) for ten consecutive days (dpi 5 to 14).

Journal: Frontiers in Cellular and Infection Microbiology

Article Title: Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

doi: 10.3389/fcimb.2021.617917

Figure Lengend Snippet: Parasitemia and cumulative mortality of mice infected with T. cruzi (Y strain) treated with vehicle or different co-administration proportions of posaconazole and tomatidine hydrochloride (Posa 1.25 + TH 5, Posa 1.25 + TH 3.75 and Posa 1.25 + TH 0.5 mpk) for ten consecutive days (dpi 5 to 14).

Article Snippet: Amitryptiline (hydrochloride), FTY720, FTY720 phosphate, AMP-deoxynojirimicin, D609 (potassium salt), fumonisin B1, myriocin, Ro48-8071, TMP-153, GW4869 (hydrochloride hydrate), PDMP (hydrochloride), tomatidine hydrochloride (TH) were purchased from Cayman chemicals and bezafibrate, quinuclidine hydrochloride, 3-aminoquinuclidine dihydrochloride, and posaconazole (Posa) were from Sigma-Aldrich Switzerland.

Techniques: Infection